Spironolactone (Aldactone) Prášek | CERTIFIKAČNÍ ÚŘADY 52-01-7 | AR Antagonist

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Spironolactone (Aldactone) Prášek | CERTIFIKAČNÍ ÚŘADY 52-01-7 | AR Antagonist

CATEGORY AND TAGS:
Ostatní rozhraní API , , , , , , , ,

Synonymum: Aldactone; Antisterone; spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CERTIFIKAČNÍ ÚŘADY: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S

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  • Specifications

Buy AR Antagonist Spironolactone (Aldactone) Prášek (CERTIFIKAČNÍ ÚŘADY 52-01-7) Online

 

Spironolactone Description

Spironolactone is a potent and direct antagonist of the AR, blocking androgens like testosterone from binding to and activating the receptor. The AR antagonism of spironolactone mostly underlies its antiandrogen activity and is responsible for its therapeutic benefits in the treatment of androgendependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women. In addition, the AR antagonism of spironolactone is involved in its feminizing side effects like gynecomastia in men.

 

Spironolactone Quick Details

Synonymum: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CERTIFIKAČNÍ ÚŘADY: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S
MW: 416.5735
Hustota: 1.24G / cm3
Bod tání: 198-207 ºC (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
specifická rotace -37 ° (c = 1, CHCl3)
Spironolacton Water-soluble practically insoluble
test: 99%
Vzhled: Bílý nebo téměř bílý jemný krystalický prášek

 

Spironolactone Certificate of Analysis

Jméno výrobku Spironolactone
CAS. 52-01-7 vnější balení 1KG / sáček
Datum výroby 2018.09.02 Skladovatelnost 2022.09.01
Norma přijatá EP7/USP39
Položky z analýzy Specifikace Výsledky
Vzhled white or yellowish-white powder. white powder
Solubility practically insoluble in water, soluble in ethanol(96 per cent). splňuje
Identifikace A/B/C Meet the requirements splňuje
specifická rotace 41 to − 46°(EP) 41 to − 45°(USP) -43°
Ztráta sušením Not more than 0.5% 0.08%
Sulfated ash Not more than 0.1% 0.03%
Impurity AImpurity C Not more than 0.2% N.D
Impurity FImpurity E Not more than 0.3% N.D
Impurity D Not more than 0.15% N.D
Impurity I Not more than 0.5% N.D
Other arbitrary unknown impurities Not more than 0.1% splňuje
nečistoty celkem Not more than 0.7% 0.15%
ordinary impurities(USP) Not more than 2.0% 0.05%
Free thiol compounds(EP) Not more than 0.05 mL splňuje
Free mercapto compounds(USP) Not more than 0.1mL splňuje
Chromium(EP) Not more than 50ppm splňuje
test 97.0%~103.0%(USP);97.5-102%(EP) 99.9%(USP);100.1%(EP)
Fineness 95%Not more than 20 μm splňuje
Závěr Kvalifikované

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