Spironolactone (Aldactone) Pulver | CAS 52-01-7 | AR Antagonist

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Spironolactone (Aldactone) Pulver | CAS 52-01-7 | AR Antagonist

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Synonym: Aldactone; Antisterone; spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S

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Spironolactone Description

Spironolactone is a potent and direct antagonist of the AR, blocking androgens like testosterone from binding to and activating the receptor. The AR antagonism of spironolactone mostly underlies its antiandrogen activity and is responsible for its therapeutic benefits in the treatment of androgendependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women. In addition, the AR antagonism of spironolactone is involved in its feminizing side effects like gynecomastia in men.

 

Spironolactone Quick Details

Synonym: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S
MW: 416.5735
Dichte: 1.24G / cm3
Schmelzpunkt: 198-207 ºC (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
Spezifische Drehung -37 ° (c = 1, CHCl3)
Spironolacton Water-soluble practically insoluble
Probe: 99%
Aussehen: Weiß oder fast weißes feinkristallines Pulver

 

Spironolactone Certificate of Analysis

Produktname Spironolactone
CAS-Nr. 52-01-7 äußere Verpackung 1KG / bag
Produktionsdatum 2018.09.02 Haltbarkeit 2022.09.01
Standard, der EP7/USP39
Elemente der Analyse Spezifikation Ergebnisse
Aussehen white or yellowish-white powder. white powder
Solubility practically insoluble in water, soluble in ethanol(96 per cent). Willigt
Identifizierung A/B/C Meet the requirements Willigt
Spezifische Drehung 41 to − 46°(EP) 41 to − 45°(USP) -43°
Trocknungsverlust Not more than 0.5% 0.08%
Sulfated ash Not more than 0.1% 0.03%
Impurity AImpurity C Not more than 0.2% N.D
Impurity FImpurity E Not more than 0.3% N.D
Impurity D Not more than 0.15% N.D
Impurity I Not more than 0.5% N.D
Other arbitrary unknown impurities Not more than 0.1% Willigt
Gesamtverunreinigungen Not more than 0.7% 0.15%
ordinary impurities(USP) Not more than 2.0% 0.05%
Free thiol compounds(EP) Not more than 0.05 mL Willigt
Free mercapto compounds(USP) Not more than 0.1mL Willigt
Chromium(EP) Not more than 50ppm Willigt
Probe 97.0%~103.0%(USP);97.5-102%(EP) 99.9%(USP);100.1%(EP)
Fineness 95%Not more than 20 μm Willigt
Schlussfolgerung Qualifizierte

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