Diphenhydramine Hydrochloride (Diphenhydramine HCL) Powder | Antihistamine drug

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  • Specifications

Buy Antihistamine drug Diphenhydramine Hydrochloride (Diphenhydramine HCL) Powder (CAS 147-24-0)


Diphenhydramine Hydrochloride Details

Melting point 168-172 °C
density 1.0489 (rough estimate)
refractive index 1.5800 (estimate)
Fp 9°C
storage temp. Desiccate at RT
solubility Very soluble in water, freely soluble in alcohol.
form Crystalline Powder or Adhering Crystals
color White
Water Solubility 1000 g/L
Sensitive Light Sensitive
Stability: Stable, but slowly darkens upon exposure to light. Incompatible with strong oxidizing agents.


Diphenhydramine Hydrochloride Certificate of Analysis

Item Specifications Results
Appearance White or off-white powder off-white powder
Identification A. A258nm/A253nm=1.1 A258nm/A253nm=1.1A258nm/A253nm Conform
B: IRspectrum of the sample corresponds to that of reference standard.
C: It gives the reactions of chlorides . Conform
Melting point 167-172°C 168.3-171.3°C
Solubility Very soluble in water, freely soluble in ethanol Conform
Acidity or alkalinity 0.5 mL of 0.01 M sodium hydroxide 0.32ml
Appearance of solution Clear, NMT YNMT BY6 Conform
Related substances Impurity A NMT0.5% ND
Any other impurity NMT 0.3% 0.14%
Total impurities NMT 1.0% 0.21%
Loss on drying NMT 0.5% 0.24%
Sulfated ash NMT 0.10% 0.06%
Assay 99.0%-101.0%(on anhydrous basis) 99.87%
Conclusion The results conforms with Enterprise standards


Diphenhydramine Hydrochloride Description

Diphenhydramine hydrochloride is an antihistamine with anticholinergic (drying) and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells. Diphenhydramine hydrochloride in the injectable form has a rapid onset of action. Diphenhydramine hydrochloride is widely distributed throughout the body, including the CNS. A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver.

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