Phenformin Hydrochloride Powder Biguanide Class Antidiabetic Drug

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Phenformin Hydrochloride Powder Biguanide Class Antidiabetic Drug

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What is Phenformin Hydrochloride

Phenformin hydrochloride is a white crystalline powder, with a melting point of 175 to 178 °C; it is soluble at 1 in 8 parts of water and 1 in 15 of ethanol, and practically insoluble in chloroform and ether.[citation needed] Phenformin is less polar and more lipid soluble and exhibits a higher affinity for mitochondrial membranes than metformin.[8] Its dissociation constant (pKa) is 2.7, 11.8 (at 32 °C), and partition coefficient (log P in octanol/water) = –0.8.[citation needed]

Phenformin is an antidiabetic drug from the biguanide class.

 

Phenformin Hydrochloride Specification

Product name Phenformin hydrochloride
Synonyms 1-Phenethylbiguanide hydrochloride
CAS No. 834-28-6
EINECS 212-637-3
Molecular formula C10H15N5.HCl;C10H16ClN5
Molecular weight 241.72
Appearance White powder
Melting point 175-178 ºC
Assay 99%
Packing 25Kg/drum
Application Phamaceutical Intermediates

 

More details about Phenformin

Phenformin is well absorbed after oral administration. The major metabolic reaction is aromatic hydroxylation to form 4–hydroxyphenformin, which is then conjugated with glucuronic acid. Up to about 50% of a dose is excreted in the urine in 24 h, about two–thirds in the form of unchanged drug and one–third as the hydroxy metabolite.

 

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