Trelagliptin Succinate SYR-472 Powder Anti-diabetic Drugs for Type 2 Diabetes

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Manufacturer Trelagliptin Succinate SYR-472 Powder Anti-diabetic Drugs for Type 2 Diabetes

 

Trelagliptin Succinate Specification

Product Name: Trigliptin succinate
CAS: 1029877-94-8
Standard: Corporate Standard
Natural/Synthetic: Synthetic
Source of extraction: For scientific research only
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 1KG/aluminum foil bag
Ingredients: 2-[[6-[(3R)-3-amino-1-pyridine]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidine] Methyl]-4-fluoro-benzonitrile succinate
Physical and chemical properties: white to white crystalline powder
Category: Pharmaceutical Raw Materials
Industry: Pharmaceuticals
Field: Hypotensive hypoglycemic agents
Deferred products: tetagliptin succinate tablets
Use: For Type 2 diabetes, a weekly dipeptidyl peptidase IV (DPP-4) inhibitor that selectively and persistently inhibits DPP-4 and controls blood glucose levels. DPP-4 is an enzyme that triggers the inactivation of incretins (glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)), which intestines lower blood sugar Regulation plays an important role.Inhibiting DPP-4 can increase blood glucose level-dependent insulin secretion and thus control blood glucose levels.
Usage and dosage: Oral administration of tutrigliflozin 100 mg once a week for adults.

 

Trelagliptin Succinate Certificate of Analysis

 

Product name Trelagliptin Succinate
CAS No. 1029877-94-8 Outer Packing 1kg/foil bag
Production date 2018.02.06 Shelf life 2020.02.05
Standard adopted Enterprise Standard
Items of analysis Specification Results
Appearance White to off-white crystalline powder White crystalline powder
Solubility This product is soluble in dimethyl sulfoxide or water, slightly soluble in methanol, slightly soluble in absolute ethanol, very slightly soluble in acetonitrile, almost insoluble in dichloromethane. Conforms
Melting point 184~189℃ 185~188℃
Specific rotation +17°~ +23° +22°
HPLC The retention time of the main peak of the test solution should be the same as the retention time of the main peak of the reference solution. Conforms
IR This product’s infrared absorption spectrum should be consistent with the reference map Conforms
Chloride ≤0.02% Conforms
Max single Impurty ≤0.1% 0.07%
Total impurities ≤0.40% 0.15%
Corresponding isomers ≤0.50% N D
Ethanol ≤0.5% 0.015%
Dichloromethane ≤0.06% N D
Toluene ≤0.089% N D
Moisture ≤0.5% 0.13%
Residue on ignition ≤0.1% Conforms
Heavy metal ≤20 parts per million Conforms
Assay In terms of anhydrous, C18H20FN5O2·C4H6O4 should be 98.5% to 101.5% 99.8%
Conclusion Qualified

 

What is Trelagliptin Succinate?

Trelagliptin, also known as SYR-472, is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed by Takeda for the treatment of type 2 diabetes (T2D).

Once-weekly SYR-472 treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes. It was well tolerated and might be a new treatment option for patients with this disease. Trelagliptin (Zafatek) was approved in Japan for the treatment of type 2 diabetes mellitus.

 

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