Furazolidone Powder (CAS 67-45-8) | Farmaceutische grondstoffen

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Buy 99.82% Pharmaceutical Raw Materials Furazolidone Powder (CAS 67-45-8)

 

Furazolidone Quick Details

  • Productnaam: Furazolidones
  • CAS-nr: 67-45-8
  • EINEC: S200-653-3
  • Molecuulformule: C8H7N3O5
  • M. W: 225.16
  • Uiterlijk: Pale yellow crystalline powder
  • Dichtheid: 1.6 g/cm3
  • Smeltpunt: 254-256° C (DEC. )
  • Boiling Point: 342.6 ° C at 760 mmHg
  • Flash Point: 161 ° C

 

Furazolidone Description

Furazolidone is a nitrofuran antibacterial agent and monoamine oxidase inhibitor (MAOI). Furazolidone has been used in human and veterinary medicine. It has a broad spectrum of activity being active against

 

Furazolidone Certificate of Analysis

Norm die is goedgekeurd BP
Items van analyse Specificatie Resultaten
Description A White or almost white powder Almost white powder
Solubility Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethanol (96%) and in methanol voldoet
EEN By Melting range Between 244 and 248°C
B By IR To match with working standard
C By TLC The principal spot in the chromatogram obtained with the test solution should be similar in position and size to the principal spot in the chromatogram obtained
D Test for non-nitrogen substituted barbiturates with reference solution (a)with reference solution (a) A violet blue color and precipitate should be appear.
Appearance of the Solution The solution should be clear and not more intensely colored than reference solution Y voldoet
Impurity-A Not more than 0.25 0.18
Impurity-B Not more than 0.25 Niet gedetecteerd
Impurity-C Not more than 0.25 Niet gedetecteerd
Impurity-D Not more than 0.25 0.20
Impurity-E Not more than 0.25 Niet gedetecteerd
Impurity-F Not more than 0.25 Niet gedetecteerd
Un specified Impurities Not more than 0.10 Niet gedetecteerd
Total Impurity Not more than 0.5 0.38
Zware metalen (ppm) Not more than 20 Minder dan 20
Description A White or almost white powder Almost white powder
Solubility Practically insoluble in water, soluble in dimethylformamide, slightly soluble in ethanol (96%) and in methanol voldoet
EEN By Melting range Between 244 and 248°C
B By IR To match with working standard
C By TLC The principal spot in the chromatogram obtained with the test solution should be similar in position and size to the principal spot in the chromatogram obtained
D Test for non-nitrogen substituted barbiturates with reference solution (a)with reference solution (a) A violet blue color and precipitate should be appear.
Appearance of the Solution The solution should be clear and not more intensely colored than reference solution Y voldoet
Impurity-A Not more than 0.25 0.18
Impurity-B Not more than 0.25 Niet gedetecteerd
Impurity-C Not more than 0.25 Niet gedetecteerd
Impurity-D Not more than 0.25 0.20
Impurity-E Not more than 0.25 Niet gedetecteerd
Impurity-F Not more than 0.25 Niet gedetecteerd
Un specified Impurities Not more than 0.10 Niet gedetecteerd
Total Impurity Not more than 0.5 0.38
Zware metalen (ppm) Not more than 20 Minder dan 20
Gewichtsverlies bij drogen (%, w/w) Not more than 0.5 0.24
Sulphated Ash (%, w/w) Not more than 0.1 0.05
Assay By titrimetry,(%, w/w) (On dried Basis) Not less than 99.0 and Not more than 101.0 99.82
Methanol Not more than 3000 753 ppm
Methyl Isobutyl ketone Not more than 5000 Niet gedetecteerd
Methyl acetate Not more than 5000 Niet gedetecteerd
Toluene Not more than 890 18 ppm
Remarks : The material Complies / does not complies to the BP specifications
Conclusie Gekwalificeerd

 

Furazolidone Application

1. In humans it has been used to treat diarrhoea and enteritis caused by bacteria or protozoan infections, including traveler’s diarrhoea, cholera and bacteremic salmonellosis. Use in treating Helicobacter pylori infections has also been proposed.
2. Furazolidone has also been used for giardiasis (due to Giardia lamblia), amoebiasis and shigellosis also though it is not a first line treatment.
3.As a veterinary medicine, furazolidone has been used with some success to treat salmonids for Myxobolus cerebralis infections.
4. It has also been used in aquaculture.
5. It is used to differentiate micrococci and staphylococci.

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