Phentolamine Mesilate Powder | CAS 65-28-1 | Nonselective a-adrenergic blocking drug

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Buy Nonselective a-adrenergic blocking drug Phentolamine Mesilate Powder (CAS 65-28-1)

 

Phentolamine Mesilate Details

Alias: VASOMAX;phentolaminemethanesulphonate; phentolamine methanesulfonate; Phentolamine methanesulfonate salt; phentolamine mesilate
CAS: 65-28-1
EINECS Number: 200-604-6
Formula: C18H23N3O4S
MW: 377.4579
Melting point: 180-182 ℃
Boiling point: 551 ° C at 760 mmHg
Flash Point: 287 ° C
Water-soluble: 50 mg / mL
Vapor Pressure: 9.48E-13mmHg at 25 ° C
Appearance: white powder

 

What is Phentolamine Mesilate?

Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor.

 

Phentolamine Mesilate Certificate of Analysis

Standard adopted USP 30
Items of analysis Specification Results
Apearance White crystalline powder Conforms
Identification IR. UV. RF value Conforms
Loss on drying Not more than 0.5% 0.18%
Residue on ignition Not more than 0.1% 0.06%
Sulfate Not more than 0.2% 0.11%
Chromatographic purity Total: not more than 1.0% 0.55%
Chromatographic purity Individual: not more than 0.5% 0.19%
Assay Between 98.0% and 102.0% 99.40%
Conclusion Qualified

 

Phentolamine Mesilate Usage

Prevention or control of hypertensive episodes in patients with pheochromocytoma (excluding OraVerse ); pharmacologic test for pheochromocytoma (not method of choice) (excluding OraVerse ); prevention and treatment of dermal necrosis and sloughing following IV administration or extravasation of norepinephrine (excluding OraVerse ); reversal of soft-tissue anesthesia (ie, anesthesia of lip and tongue) ( OraVerse only).

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