Febuxostat Powder Drug Treat Chronic Gout and Hyperuricemia

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Buy Febuxostat Powder Drug Treat Chronic Gout and Hyperuricemia Online

 

Febuxostat Specification

Product Name: Febuxostat
CAS: 144060-53-7
Natural/Synthetic: Synthetic
Extraction source: A crystal form
Level: Pharmaceutical grade
Content: 99%
Appearance: white powder
Packing: 1KG/aluminum foil bag
Ingredients: 2-[3-Cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid
Physical and chemical properties: white or almost white powder; no smell, no taste. This product is dissolved in acetonitrile, acetone, methanol
Category: Pharmaceutical Raw Materials
Industry: Pharmaceuticals
Field: Anti gout drugs
Deferred products: febuxostat tablets, capsules
Application: Chronic hyperuricemia for the treatment of gout
Usage and dosage: once a day, 80mg once, and take it with food. After 2 to 4 weeks of treatment, if the serum uric acid value is higher than 6 mg/dL (357 μmol/L), increase the dose to 120 mg/day.

 

Febuxostat Certificate of Analysis

Product name Febuxostat
CAS No. 144060-53-7 Outer Packing Foil bag
Production date 2018.2.10 Shelf life 2020.2.9
Standard adopted Enterprise Standard
Items of analysis Specification Results
Appearance White to almost white crystalline powder, odorless White crystalline powder, odorless
Solubility Easily soluble in N,N-Dimethylformamide, soluble in Dimethyl sulfoxide. Sparingly soluble in Chloroform.Sligt soluble in methanol, practically insoluble in water Conforms
m.p. 207℃~211℃ 207.5℃~208.5℃
Identification Conforms Conforms
ImpurityⅠ NMT0.1% N.D.
ImpurityⅡ NMT0.1% N.D.
ImpurityⅢ NMT0.1% N.D.
ImpurityⅣ NMT0.1% 0.02%
Water ≤2.0% 0.5%
Residue on ignition ≤0.1% 0.02%
Heavy metals ≤20ppm Conforms
Ethanol ≤5000ppm 23ppm
Tetrahydrofuran ≤720ppm N.D.
N-hexane ≤290ppm N.D.
N,N-Dimethylformamide ≤880ppm N.D.
Dichloromethane ≤600ppm 24ppm
Assay 98.0%~102.0%(Calculated as anhydrous basis) 99.2%
Solubility Easily soluble in N,N-Dimethylformamide, soluble in Dimethyl sulfoxide. Sparingly soluble in Chloroform.Sligt soluble in methanol, practically insoluble in water Conforms
m.p. 207℃~211℃ 207.5℃~208.5℃
Identification Conforms Conforms
ImpurityⅠ NMT0.1% N.D.
ImpurityⅡ NMT0.1% N.D.
ImpurityⅢ NMT0.1% N.D.
ImpurityⅣ NMT0.1% 0.02%
Water ≤2.0% 0.5%
Residue on ignition ≤0.1% 0.02%
Heavy metals ≤20ppm Conforms
Ethanol ≤5000ppm 23ppm
Tetrahydrofuran ≤720ppm N.D.
N-hexane ≤290ppm N.D.
N,N-Dimethylformamide ≤880ppm N.D.
Dichloromethane ≤600ppm 24ppm
Assay 98.0%~102.0%(Calculated as anhydrous basis) 99.2%
Conclusion Qualified

 

Febuxostat Common Side effects

The adverse effects associated with febuxostat therapy include nausea, diarrhea, arthralgia, headache, increased hepatic serum enzyme levels and rash.

 

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