Promethazine Hydrochloride (Promethazine hcl) Praf | Antihistamine Raw Drug | CAS 58-33-3

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Buy Antihistamine Raw Drug Promethazine Hydrochloride (Promethazine hcl) Powder Online

 

Promethazine hydrochloride Description

Promethazine hydrochloride is a prescription drug. It’s available as an oral solution, a rectal suppository, and an oral tablet.

Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain

 

Promethazine hydrochloride Quick Details

CAS Nr:58-33-3
Aspect:white to off-white powder
Molecular Structure:C17H20N2S.HCl
Test: 99%
Odor:Odorless
Storage:sealed save, cool ventilated dry place away from moisture and strong light
Chemical Properties:White Solid
folosire:Antihistaminic, antiemetic, CNS depressant
folosire:stool softener
folosire:For the treatment of allergic disorders, and nausea/vomiting.

 

Promethazine hydrochloride Certificate of Analysis

Numele produsului Promethazine hydrochloride
CAS. 58-33-3 exterioară de ambalare 25kg / tambur
Data fabricatiei Jan.2019 Termen de valabilitate Dec.2022
standard adoptat BP/USP
Elemente de analiză Specificație Rezultate
Aspect a white or faintly yellowish crystalline powder a white crystalline powder
solubility very soluble in water,freely soluble in alcohol and in methylene chloride.freely soluble in hot dehydrated alcohol and in chloroform.practically insoluble in ether,in acetone and in ethyl acetate. complies
melting point it melts at about 222 ° with decomposition it melts at about 222.4° with decomposition
completeness and clarity of solution(10% in water)(10% in chlorofrom) shall be practically clear and not more than a light yellow color. clear and colorless
identification    
A.By IR Spectrum the position and relative sizes of the bands in the spectrum of the sample and reference spectrum shall be concordant. the position and relative sizes of the bands in the spectrum of the sample and reference spectrum are concordant
B.by TLC it complies with the identification test for phenothiazines it complies with the identification test for phenothiazines.
C.Test with Nitric Acid forms orange colored solution and orange red precipitate forms orange colored solution and orange red precipitate.
D.test for chlorides shall comply the test. complies with test for chlorides
Acidity    
10% w/v solution 4.0-5.0 4.37
1 in 20 solution 4.0-5.0 4.62
related substance By HPLC    
impurity A NMT 0.1% ND
impurity B NMT 0.8% 0.15%
impurity C NMT 0.2% 0.05%
impurity D NMT 0.1% ND
Unspecified impurity NMT 0.1% 0.02%
total impurities NMT 1.2% 0.22%
related substance by TLC(as per USP)    
single impurity NMT 1.0% 0.25%
sum of impurities NMT 2.0% 0.45%
heavy metals NMT 10 ppm less than 10 ppm
loss on drying at 105℃ NMT 0.5% w/w 0.16%
sulphate ash NMT 0.1% w/w 0.01%
assay 99%-101% w/w as per BP;97%-101.5% w/w as per USP 99.8%
Solventi reziduali    
class 1 solvents —– not used in our mfg.process
class 2 solvents o-xylene ICH Limits:2170ppm 813 ppm
class 3 solvents Isopropyl alcohol ICH Limits:5000ppm 362 ppm
Concluzie Calificat

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