Spironolactone (Aldactone) Powder | CAS 52-01-7 | AR Antagonist

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Spironolactone (Aldactone) Powder | CAS 52-01-7 | AR Antagonist

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Synonym: Aldactone; Antisterone; spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S

  • Specifications

Buy AR Antagonist Spironolactone (Aldactone) Powder (CAS 52-01-7) Online


Spironolactone Description

Spironolactone is a potent and direct antagonist of the AR, blocking androgens like testosterone from binding to and activating the receptor. The AR antagonism of spironolactone mostly underlies its antiandrogen activity and is responsible for its therapeutic benefits in the treatment of androgen – dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women. In addition, the AR antagonism of spironolactone is involved in its feminizing side effects like gynecomastia in men.


Spironolactone Quick Details

Synonym: Aldactone;Antisterone;spirolactone;7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,
17-beta- carbolactone
CAS: 52-01-7
EINECS: 200-133-6
MF: C24H32O4S
MW: 416.5735
Density: 1.24g / cm3
Melting point: 198-207 ºC (dec.)
Boiling point: 597 ° C at 760 mmHg
Flash Point: 302.2 ° C
Water-soluble: practically insoluble
Vapor Pressure: 3.24E-14mmHg at 25 ° C
Specific rotation -37 ° (c = 1, CHCl3)
Spironolacton Water-soluble practically insoluble
Assay: 99%
Appearance: White or almost white fine crystalline powder


Spironolactone Certificate of Analysis

Product name Spironolactone
CAS No. 52-01-7 Outer Packing 1KG/bag
Production date 2018.09.02 Shelf life 2022.09.01
Standard adopted EP7/USP39
Items of analysis Specification Results
Appearance white or yellowish-white powder. white powder
Solubility practically insoluble in water, soluble in ethanol(96 per cent). Complies
Identification A/B/C Meet the requirements Complies
Specific rotation − 41 to − 46°(EP);− 41 to − 45°(USP) -43°
Loss on drying Not more than 0.5% 0.08%
Sulfated ash Not more than 0.1% 0.03%
Impurity A;Impurity C Not more than 0.2% N.D
Impurity F;Impurity E Not more than 0.3% N.D
Impurity D Not more than 0.15% N.D
Impurity I Not more than 0.5% N.D
Other arbitrary unknown impurities Not more than 0.1% Complies
Total impurities Not more than 0.7% 0.15%
ordinary impurities(USP) Not more than 2.0% 0.05%
Free thiol compounds(EP) Not more than 0.05 mL Complies
Free mercapto compounds(USP) Not more than 0.1mL Complies
Chromium(EP) Not more than 50ppm Complies
Assay 97.0%~103.0%(USP);97.5-102%(EP) 99.9%(USP);100.1%(EP)
Fineness 95%Not more than 20 μm Complies
Conclusion Qualified

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